Performance Improvement Plan for Developing Countries

This paper highlights the various dimensions of Performance Improvement Plan and their implications to different organizations of developing countries. The proposed approach might be supportive in the development of model that improves the performance of developing world. Various steps of model including analyze the economic, political, and legal situation of the country, availability of resources, effective tools for improving performance, evaluation tools, develop effective communication with employees, feedback and analytical estimates. The developing countries are facing some challenges which are hinder to improve performance. These countries can improve the performance by adopting alternatives and effective management of the available resources is the key factor to improve performance. Keywords: performance, developing countries, performance improvement pla

Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes

We conduct a cartography of rhodopsin-like non-olfactory G protein-coupled receptors in the Ensembl database. The most recent genomic data (releases 90-92, 90 vertebrate genomes) are analyzed through the online interface and receptors mapped on phylogenetic guide trees that were constructed based on a set of similar to 14.000 amino acid sequences. This snapshot of genomic data suggest vertebrate genomes to harbour 142 clades of GPCRs without human orthologues. Among those, 69 have not to our knowledge been mentioned or studied previously in the literature, of which 28 are distant from existing receptors and likely new orphans. These newly identified receptors are candidates for more focused evolutionary studies such as chromosomal mapping as well for in-depth pharmacological characterization. Interestingly, we also show that 37 of the 72 human orphan (or recently deorphanized) receptors included in this study cluster into nineteen closely related groups, which implies that there are less ligands to be identified than previously anticipated. Altogether, this work has significant implications when discussing nomenclature issues for GPCRs.Peer reviewe